4e99: Difference between revisions
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==Human Serum Albumin Complex with Perfluorooctane Sulfonate Potassium== | ==Human Serum Albumin Complex with Perfluorooctane Sulfonate Potassium== | ||
<StructureSection load='4e99' size='340' side='right' caption='[[4e99]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='4e99' size='340' side='right' caption='[[4e99]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4e99]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[4e99]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E99 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E99 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P8S:HEPTADECAFLUORO-1-OCTANESULFONIC+ACID'>P8S</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P8S:HEPTADECAFLUORO-1-OCTANESULFONIC+ACID'>P8S</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ALB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ALB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e99 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4e99 RCSB], [http://www.ebi.ac.uk/pdbsum/4e99 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e99 OCA], [http://pdbe.org/4e99 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4e99 RCSB], [http://www.ebi.ac.uk/pdbsum/4e99 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4e99 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4e99" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Huang, M D]] | [[Category: Huang, M D]] | ||
[[Category: Luo, Z P]] | [[Category: Luo, Z P]] | ||
Revision as of 10:36, 4 August 2016
Human Serum Albumin Complex with Perfluorooctane Sulfonate PotassiumHuman Serum Albumin Complex with Perfluorooctane Sulfonate Potassium
Structural highlights
Disease[ALBU_HUMAN] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.[1] [2] [3] [4] Function[ALBU_HUMAN] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.[5] Publication Abstract from PubMedPerfluorooctane sulfonate (PFOS) is a man-made fluorosurfactant and globally persistent organic pollutant. PFOS is mainly distributed in blood with a long half-life for elimination. PFOS was found mainly bound to human serum albumin (HSA) in plasma, the most abundant protein in human blood plasma, which transports a variety of endogenous and exogenous ligands. However, the structural basis of such binding remains unclear. Here, we report the crystal structure of the HSA-PFOS complex and show that PFOS binds to HSA at a molar ratio of 2:1. In addition, PFOS binding renders the HSA structure more compact. Our results provide a structural mechanism to understand the retention of surfactants in human serum. Structural evidence of perfluorooctane sulfonate transport by human serum albumin.,Luo Z, Shi X, Hu Q, Zhao B, Huang M Chem Res Toxicol. 2012 May 21;25(5):990-2. Epub 2012 Apr 16. PMID:22482699[6] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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