3q0h: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q0h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q0h RCSB], [http://www.ebi.ac.uk/pdbsum/3q0h PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q0h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q0h RCSB], [http://www.ebi.ac.uk/pdbsum/3q0h PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/TIGIT_HUMAN TIGIT_HUMAN]] Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 18:20, 25 December 2014
Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT)Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT)
Structural highlights
Function[TIGIT_HUMAN] Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. |
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