3o1g: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Cathepsin K covalently bound to a 2-cyano pyrimidine inhibitor with a benzyl P3 group.== | ==Cathepsin K covalently bound to a 2-cyano pyrimidine inhibitor with a benzyl P3 group.== | ||
<StructureSection load='3o1g' size='340' side='right' caption='[[3o1g]], [[Resolution|resolution]] 1.65Å' scene=''> | <StructureSection load='3o1g' size='340' side='right' caption='[[3o1g]], [[Resolution|resolution]] 1.65Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3o1g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3o1g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O1G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O1G FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=O75:N-BENZYL-3-(2-CYANO-6-PROPYLPYRIMIDIN-4-YL)-N-[2-(DIMETHYLAMINO)ETHYL]-5-(TRIFLUOROMETHYL)BENZAMIDE'>O75</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=O75:N-BENZYL-3-(2-CYANO-6-PROPYLPYRIMIDIN-4-YL)-N-[2-(DIMETHYLAMINO)ETHYL]-5-(TRIFLUOROMETHYL)BENZAMIDE'>O75</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3o0u|3o0u]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3o0u|3o0u]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTSK, CTSO, CTSO2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTSK, CTSO, CTSO2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o1g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3o1g RCSB], [http://www.ebi.ac.uk/pdbsum/3o1g PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o1g OCA], [http://pdbe.org/3o1g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3o1g RCSB], [http://www.ebi.ac.uk/pdbsum/3o1g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3o1g ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| Line 21: | Line 22: | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3o1g ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
| Line 31: | Line 32: | ||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 3o1g" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
| Line 39: | Line 41: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Cathepsin K]] | [[Category: Cathepsin K]] | ||
[[Category: | [[Category: Human]] | ||
[[Category: Fradera, X]] | [[Category: Fradera, X]] | ||
[[Category: Uitdehaag, J C.M]] | [[Category: Uitdehaag, J C.M]] | ||