3izo: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3izo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3izo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3izo RCSB], [http://www.ebi.ac.uk/pdbsum/3izo PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3izo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3izo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3izo RCSB], [http://www.ebi.ac.uk/pdbsum/3izo PDBsum]</span></td></tr> | ||
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== Function == | |||
[[http://www.uniprot.org/uniprot/PEN3_ADE05 PEN3_ADE05]] Major capsid protein that self-associates to form penton base pentamers, each in the shape of a pentagon, situated at the 12 verteces of the pseudo T=25 capsid. Involved in virus secondary attachment to host cell after initial attachment by the fiber protein. Binds host integrin heterodimer ITGAV-ITGB5 (alphaV-beta5) thereby triggering clathrin-mediated endocytosis of virions. Mediates initial virus attachment to CXADR-negative cells. Binding to integrins ITGAV-ITGB5 also seems to induce macropinocytosis uptake of the virus. As the virus enters the host cell, penton proteins are shedded concomitant with virion acidification in the endosome.<ref>PMID:20615244</ref> <ref>PMID:20798312</ref> | |||
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== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||