2yhf: Difference between revisions
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==1.9 ANGSTROM CRYSTAL STRUCTURE OF CLEC5A== | ==1.9 ANGSTROM CRYSTAL STRUCTURE OF CLEC5A== | ||
<StructureSection load='2yhf' size='340' side='right' caption='[[2yhf]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='2yhf' size='340' side='right' caption='[[2yhf]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2yhf]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2yhf]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YHF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YHF FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yhf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yhf RCSB], [http://www.ebi.ac.uk/pdbsum/2yhf PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yhf OCA], [http://pdbe.org/2yhf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yhf RCSB], [http://www.ebi.ac.uk/pdbsum/2yhf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yhf ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/CLC5A_HUMAN CLC5A_HUMAN]] Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation (By similarity). Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release.<ref>PMID:10449773</ref> <ref>PMID:18496526</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2yhf" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Callaghan, C A.O]] | [[Category: Callaghan, C A.O]] | ||
[[Category: Hall, B A]] | [[Category: Hall, B A]] | ||