Molecular Playground/ClyA: Difference between revisions
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<Structure load='1QOY' size='500' frame='true' align='right' caption=' | <Structure load='1QOY' size='500' frame='true' align='right' caption='ClyA complex with sulfate (PDB code [[1qoy]]).' scene='Insert optional scene name here' /> | ||
==Introduction== | ==Introduction== | ||
Pore-forming toxins (PFTs) are virulence factors secreted by pathogenic organisms. These are proteins that form transmembrane channels on target cell membranes. They cause cell death by making the cell membrane permeable, leading to osmotic imbalance and lysis. There are two classes of PFTs based on their secondary structure, alpha-PFTs and beta-PFTs. Cytolysin A (ClyA) is an alpha-PFT and is secreted by ''Salmonella'', ''Shigella'' and ''E. coli'' strains. | Pore-forming toxins (PFTs) are virulence factors secreted by pathogenic organisms. These are proteins that form transmembrane channels on target cell membranes. They cause cell death by making the cell membrane permeable, leading to osmotic imbalance and lysis. There are two classes of PFTs based on their secondary structure, alpha-PFTs and beta-PFTs. '''Cytolysin A (ClyA)''' is an alpha-PFT and is secreted by ''Salmonella'', ''Shigella'' and ''E. coli'' strains. | ||
==About Cytolysin A== | ==About Cytolysin A== | ||