Molecular Playground/ClyA: Difference between revisions
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The protomer of ClyA reveals slight differences between the monomer and protomer (from the dodecameric oligomer). The major conformational changes between the monomer and the protomer are the positions of the <B><font color="blue">N-terminal helix</font></B> and the <B><font color="purple">beta-tongue</font></B>. As ClyA oligomerizes and forms a pore, the N-terminal helix swings to the opposite side of the molecule while the beta-tongue changes its conformation and turns into an alpha-helix that interacts with the lipid bilayer. | The protomer of ClyA reveals slight differences between the monomer and protomer (from the dodecameric oligomer). The major conformational changes between the monomer and the protomer are the positions of the <B><font color="blue">N-terminal helix</font></B> and the <B><font color="purple">beta-tongue</font></B>. As ClyA oligomerizes and forms a pore, the N-terminal helix swings to the opposite side of the molecule while the beta-tongue changes its conformation and turns into an alpha-helix that interacts with the lipid bilayer. | ||
<scene name='57/571278/Clya_oligomer/ | <scene name='57/571278/Clya_oligomer/3'>The oligomeric form of ClyA with a protomer highlighted in crimson</scene> | ||
Its crystal structure, [[2WCD]], reveals a dodecamer. Larger [http://pubs.acs.org/doi/abs/10.1021/ja4053398 pores] have been isolated, as well. A few research endeavors involving ClyA include using [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839435/ ClyA as part of cancer therapy], as well as a [http://www.nature.com/ncomms/2013/130912/ncomms3415/full/ncomms3415.html DNA delivery vehicle]. | Its crystal structure, [[2WCD]], reveals a dodecamer. Larger [http://pubs.acs.org/doi/abs/10.1021/ja4053398 pores] have been isolated, as well. A few research endeavors involving ClyA include using [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839435/ ClyA as part of cancer therapy], as well as a [http://www.nature.com/ncomms/2013/130912/ncomms3415/full/ncomms3415.html DNA delivery vehicle]. | ||