1roo: Difference between revisions

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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1roo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1roo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1roo RCSB], [http://www.ebi.ac.uk/pdbsum/1roo PDBsum]</span></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1roo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1roo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1roo RCSB], [http://www.ebi.ac.uk/pdbsum/1roo PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/TXSHK_STOHE TXSHK_STOHE]] Inhibits voltage-dependent potassium channels. Inhibits Kv1.3/KCNA3 potently and also blocks Kv1.1/KCNA1, Kv1.4/KCNA4, and Kv1.6/KCNA6 at subnanomolar concentrations.<ref>PMID:7660365</ref> 


==See Also==
==See Also==
*[[Potassium channel toxin|Potassium channel toxin]]
*[[Potassium channel toxin|Potassium channel toxin]]
== References ==
<references/>
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</StructureSection>
</StructureSection>

Revision as of 22:27, 25 December 2014

NMR SOLUTION STRUCTURE OF SHK TOXIN, NMR, 20 STRUCTURESNMR SOLUTION STRUCTURE OF SHK TOXIN, NMR, 20 STRUCTURES

Structural highlights

1roo is a 1 chain structure with sequence from Stichodactyla helianthus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[TXSHK_STOHE] Inhibits voltage-dependent potassium channels. Inhibits Kv1.3/KCNA3 potently and also blocks Kv1.1/KCNA1, Kv1.4/KCNA4, and Kv1.6/KCNA6 at subnanomolar concentrations.[1]

See Also

References

  1. ↑ Castaneda O, Sotolongo V, Amor AM, Stocklin R, Anderson AJ, Harvey AL, Engstrom A, Wernstedt C, Karlsson E. Characterization of a potassium channel toxin from the Caribbean Sea anemone Stichodactyla helianthus. Toxicon. 1995 May;33(5):603-13. PMID:7660365
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