Transaldolase: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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 {{STRUCTURE_3tno| PDB=3tno  | SIZE=400| SCENE= |right|CAPTION=Transaldolase dimer complex with sedoheptulose 7-phosphate and Cl- (green) ion, [[3tno]] }}
+== Function ==
+'''Transaldolase''' (TAL) is part of the pentose phosphate pathway.  It catalyzes the transformation of sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate<ref>PMID:15960612</ref>.
-'''Transaldolase''' (TAD) is part of the pentose phosphate pathway.  It catalyzes the transformation of sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate.
+== Disease ==
+TAL deficiency influences mitochondrial homeostasis, Ca+2 fluxing and apoptosis<ref>PMID:18498245</ref>.
+== Structural highlights ==
+TAL overall structure is of a TIM barrel.  The active site contains a Schiff-base-bound phosphosugar at Lys135<ref>PMID:24531488</ref>.
 == 3D Structures of transaldolase ==
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 *Transaldolase
-**[[3clm]] – TAD – ''Neisseria gonorrhoeae''<br />
+**[[3clm]] – TAL – ''Neisseria gonorrhoeae''<br />
-**[[3cwn]],  [[1onr]], [[1ucw]] - EcTAD B – ''Escherichia coli''<br />
+**[[3cwn]],  [[1onr]], [[1ucw]] - EcTAL B – ''Escherichia coli''<br />
-**[[3kof]], [[1i2n]], [[1i2o]], [[1i2p]], [[1i2q]], [[1i2r]] - EcTAD B (mutant)<br />
+**[[3kof]], [[1i2n]], [[1i2o]], [[1i2p]], [[1i2q]], [[1i2r]] - EcTAL B (mutant)<br />
-**[[3hjz]] – TAD B – ''Prochlorococcus marinus''<br />
+**[[3hjz]] – TAL B – ''Prochlorococcus marinus''<br />
-**[[3igx]], [[4e0c]] – FtTAD B – ''Francisella tularensis''<br />
+**[[3igx]], [[4e0c]] – FtTAL B – ''Francisella tularensis''<br />
-**[[3m16]] – TAD – ''Oleispira Antarctica''<br />
+**[[3m16]] – TAL – ''Oleispira Antarctica''<br />
-**[[3r8r]] – TAD – ''Bacillus subtilis''<br />
+**[[3r8r]] – TAL – ''Bacillus subtilis''<br />
-**[[3r5e]] – TAD – ''Corynebacterium glutamicum''<br />
+**[[3r5e]] – TAL – ''Corynebacterium glutamicum''<br />
-**[[1f05]] – TAD – human<br />
+**[[1f05]] – TAL – human<br />
-**[[1vpx]] – TAD – ''Thermotoga maritima''<br />
+**[[1vpx]] – TAL – ''Thermotoga maritima''<br />
-**[[1wx0]] – TAD – ''Thermus thermophilus''<br />
+**[[1wx0]] – TAL – ''Thermus thermophilus''<br />
-**[[2cwn]], [[2e1d]] – TAD (mutant) – mouse<br />
+**[[2cwn]], [[2e1d]] – TAL (mutant) – mouse<br />
 *Transaldolase binary complexes
-**[[3tk7]] - FtTAD B + fructose 6-phosphate<br />
+**[[3tk7]] - FtTAL B + fructose 6-phosphate<br />
-**[[3te9]] - FtTAD B (mutant) + fructose 6-phosphate<br />
+**[[3te9]] - FtTAL B (mutant) + fructose 6-phosphate<br />
-**[[3tkf]] - FtTAD B (mutant) + seduheptulose 7-phosphate<br /`>
+**[[3tkf]] - FtTAL B (mutant) + seduheptulose 7-phosphate<br /`>
-**[[3tno]] - FtTAD B + seduheptulose 7-phosphate<br />
+**[[3tno]] - FtTAL B + seduheptulose 7-phosphate<br />
-**[[3upb]] - FtTAD B + arabinose 5-phosphate<br />
+**[[3upb]] - FtTAL B + arabinose 5-phosphate<br />
 }}
+== References ==
+<references/>
 [[Category:Topic Page]]