4i2s: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i2s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4i2s RCSB], [http://www.ebi.ac.uk/pdbsum/4i2s PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i2s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4i2s RCSB], [http://www.ebi.ac.uk/pdbsum/4i2s PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT]] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref> <ref>PMID:22036948</ref> | |||
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== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||