3v7k: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v7k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v7k RCSB], [http://www.ebi.ac.uk/pdbsum/3v7k PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v7k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v7k RCSB], [http://www.ebi.ac.uk/pdbsum/3v7k PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/DPOLB_RAT DPOLB_RAT]] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. | |||
==See Also== | ==See Also== | ||
Revision as of 00:48, 26 December 2014
Co-crystal structure of K72E variant of rat polymerase beta: Enzyme-DNA binary complexCo-crystal structure of K72E variant of rat polymerase beta: Enzyme-DNA binary complex
Structural highlights
Function[DPOLB_RAT] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. See Also |
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