3vzw: Difference between revisions
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==Crystal Structure of outer membrane protein PorB from Neisseria meningitidis in complex with galactose== | ==Crystal Structure of outer membrane protein PorB from Neisseria meningitidis in complex with galactose== | ||
<StructureSection load='3vzw' size='340' side='right' caption='[[3vzw]], [[Resolution|resolution]] 3.20Å' scene=''> | <StructureSection load='3vzw' size='340' side='right' caption='[[3vzw]], [[Resolution|resolution]] 3.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3vzw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3vzw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplokokkus_intracellularis_meningitidis"_(sic)_weichselbaum_1887 "diplokokkus intracellularis meningitidis" (sic) weichselbaum 1887]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3a2t 3a2t]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VZW FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3vzt|3vzt]], [[3vzu|3vzu]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3vzt|3vzt]], [[3vzu|3vzu]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vzw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vzw RCSB], [http://www.ebi.ac.uk/pdbsum/3vzw PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vzw OCA], [http://pdbe.org/3vzw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3vzw RCSB], [http://www.ebi.ac.uk/pdbsum/3vzw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3vzw ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 3vzw" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Porin|Porin]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Iverson, T M]] | [[Category: Iverson, T M]] | ||
[[Category: Tanabe, M]] | [[Category: Tanabe, M]] | ||
[[Category: Membrane protein]] | [[Category: Membrane protein]] | ||
[[Category: Transport]] | [[Category: Transport]] | ||
Revision as of 22:10, 10 December 2016
Crystal Structure of outer membrane protein PorB from Neisseria meningitidis in complex with galactoseCrystal Structure of outer membrane protein PorB from Neisseria meningitidis in complex with galactose
Structural highlights
Publication Abstract from PubMedPorB is the second most prevalent outer membrane protein in Neisseria meningitidis. PorB is required for neisserial pathogenesis and can elicit a Toll-like receptor mediated host immune response. Here, the x-ray crystal structure of PorB has been determined to 2.3 A resolution. Structural analysis and cocrystallization studies identify three putative solute translocation pathways through the channel pore: One pathway transports anions nonselectively, one transports cations nonselectively, and one facilitates the specific uptake of sugars. During infection, PorB likely binds host mitochondrial ATP, and cocrystallization with the ATP analog AMP-PNP suggests that binding of nucleotides regulates these translocation pathways both by partial occlusion of the pore and by restricting the motion of a putative voltage gating loop. PorB is located on the surface of N. meningitidis and can be recognized by receptors of the host innate immune system. Features of PorB suggest that Toll-like receptor mediated recognition outer membrane proteins may be initiated with a nonspecific electrostatic attraction. Structural basis for solute transport, nucleotide regulation, and immunological recognition of Neisseria meningitidis PorB.,Tanabe M, Nimigean CM, Iverson TM Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6811-6. Epub 2010 Mar 29. PMID:20351243[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences |
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