1n4y: Difference between revisions
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|GENE= RHOD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8717 Calloselasma rhodostoma]) | |GENE= RHOD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8717 Calloselasma rhodostoma]) | ||
|DOMAIN= | |||
|RELATEDENTRY=[[1kst|1KST]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4y OCA], [http://www.ebi.ac.uk/pdbsum/1n4y PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1n4y RCSB]</span> | |||
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[[Category: venom]] | [[Category: venom]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:25:25 2008'' | ||
Revision as of 22:25, 30 March 2008
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| Gene: | RHOD (Calloselasma rhodostoma) | ||||||
| Related: | 1KST
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
REFINED STRUCTURE OF KISTRIN
OverviewOverview
The structure of kistrin, which is a member of a homologous family of glycoprotein IIb-IIIa (GP IIb-IIIa) antagonists and potent protein inhibitors of platelet aggregation, has been determined by two-dimensional nuclear magnetic resonance (NMR) spectroscopy. The 68-residue protein consists of a series of tightly packed loops held together by six disulfide bonds and has almost no regular secondary structure. Kistrin has an Arg-Gly-Asp (RGD) adhesion site recognition sequence important for binding to GP IIb-IIIa that is located at the apex of a long loop across the surface of the protein.
About this StructureAbout this Structure
1N4Y is a Single protein structure of sequence from Calloselasma rhodostoma. This structure supersedes the now removed PDB entry 1KST. Full crystallographic information is available from OCA.
ReferenceReference
Solution structure of kistrin, a potent platelet aggregation inhibitor and GP IIb-IIIa antagonist., Adler M, Lazarus RA, Dennis MS, Wagner G, Science. 1991 Jul 26;253(5018):445-8. PMID:1862345
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