3mdx: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
No edit summary
No edit summary
Line 9: Line 9:
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mdx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mdx RCSB], [http://www.ebi.ac.uk/pdbsum/3mdx PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mdx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mdx RCSB], [http://www.ebi.ac.uk/pdbsum/3mdx PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/DUT_BRUA2 DUT_BRUA2]] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.[HAMAP-Rule:MF_00116]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 17:34, 25 December 2014

Crystal structure of deoxyuridine 5-triphosphate nucleotidohydrolase from Brucella melitensis, rhombohedral crystal formCrystal structure of deoxyuridine 5-triphosphate nucleotidohydrolase from Brucella melitensis, rhombohedral crystal form

Structural highlights

3mdx is a 1 chain structure with sequence from Brucella melitensis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:dut, BAB1_1687 (Brucella melitensis)
Activity:dUTP diphosphatase, with EC number 3.6.1.23
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[DUT_BRUA2] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.[HAMAP-Rule:MF_00116]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

3mdx, resolution 1.45Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA