1myt: Difference between revisions
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|PDB= 1myt |SIZE=350|CAPTION= <scene name='initialview01'>1myt</scene>, resolution 1.74Å | |PDB= 1myt |SIZE=350|CAPTION= <scene name='initialview01'>1myt</scene>, resolution 1.74Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN IX CONTAINING FE'>HEM</scene> | |LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1myt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1myt OCA], [http://www.ebi.ac.uk/pdbsum/1myt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1myt RCSB]</span> | |||
}} | }} | ||
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[[Category: Przybylska, M.]] | [[Category: Przybylska, M.]] | ||
[[Category: Rose, D R.]] | [[Category: Rose, D R.]] | ||
[[Category: oxygen transport]] | [[Category: oxygen transport]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:23:01 2008'' | ||
Revision as of 22:23, 30 March 2008
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| , resolution 1.74Å | |||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE TO 1.74 ANGSTROMS RESOLUTION OF METMYOGLOBIN FROM YELLOWFIN TUNA (THUNNUS ALBACARES): AN EXAMPLE OF A MYOGLOBIN LACKING THE D HELIX
OverviewOverview
The crystal structure of metmyoglobin from yellowfin tuna (Thunnus albacares) has been determined by molecular replacement methods and refined to a conventional R factor of 0.177 for all observed reflections in the range of 6.0-1.70 A resolution. Like other myoglobins for which a high-resolution structure is available, the polypeptide chain is organized into several helices that cooperate to form a hydrophobic pocket into which the heme prosthetic group is non-covalently bound; however, the D helix observed in other myoglobins is absent in myoglobin from yellowfin tuna and has been replaced with a random coil. As well, the A helix has a pronounced kink due to the presence of Pro16. The differences in structure between this and sperm whale myoglobin can be correlated with their reported dioxygen affinity and dissociation. The structure is in agreement with reported fluorescence data which show an increased Trp14.heme distance in yellowfin tuna compared to sperm whale myoglobin.
About this StructureAbout this Structure
1MYT is a Single protein structure of sequence from Thunnus albacares. Full crystallographic information is available from OCA.
ReferenceReference
1.70 A resolution structure of myoglobin from yellowfin tuna. An example of a myoglobin lacking the D helix., Birnbaum GI, Evans SV, Przybylska M, Rose DR, Acta Crystallogr D Biol Crystallogr. 1994 May 1;50(Pt 3):283-9. PMID:15299440
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