Purine repressor: Difference between revisions

Revision as of 12:32, 31 July 2016

Function

Purine repressor (PurR) is a member of the lac repressor family. PurP binds DNA via a highly conserved helix-turn-helix at the N terminal (DBD). PurP contains a co-repressor binding domain as well (CBD). PurP binds to a 16-bp operator sequence and co-regulates genes which are involved in the biosynthesis of purine and pyrimidine nucleotides^[1].

Structure of purine processor complex with DNA (green) and hypoxanthine (PDB entry 1qp4)

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3D structures of purine repressor3D structures of purine repressor

Updated on 31-July-2016

ReferencesReferences

↑ Wilson HR, Turnbough CL Jr. Role of the purine repressor in the regulation of pyrimidine gene expression in Escherichia coli K-12. J Bacteriol. 1990 Jun;172(6):3208-13. PMID:1971621

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Wilson HR, Turnbough CL Jr. Role of the purine repressor in the regulation of pyrimidine gene expression in Escherichia coli K-12. J Bacteriol. 1990 Jun;172(6):3208-13. PMID:1971621

[1]

@@ Line 1: / Line 1: @@
 <StructureSection load='1qp4' size='350' side='right' caption='Structure of purine processor complex with DNA (green) and hypoxanthine (PDB entry [[1qp4]])' scene=''>
+== Function ==
-'''Purine repressor''' (PurR) is a member of the lac repressor family.  PurP binds DNA via a highly conserved helix-turn-helix at the N terminal (DBD).  PurP contains a co-repressor binding domain as well (CBD).  PurP binds to a 16-bp operator sequence and co-regulates genes which are involved in the biosynthesis of purine and pyrimidine nucleotides.
+'''Purine repressor''' (PurR) is a member of the lac repressor family.  PurP binds DNA via a highly conserved helix-turn-helix at the N terminal (DBD).  PurP contains a co-repressor binding domain as well (CBD).  PurP binds to a 16-bp operator sequence and co-regulates genes which are involved in the biosynthesis of purine and pyrimidine nucleotides<ref>PMID:1971621</ref>.
 </StructureSection>
@@ Line 25: / Line 25: @@
 **[[1zay]] - EcPurR + DNA + hypoxanthine + di-imino-purine<br />
 }}
+== References ==
+<references/>
 [[Category:Topic Page]]