PhoP-PhoQ: Difference between revisions
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<StructureSection load='2pl1' size='500' side='right' caption='BeF activated PhoP domain of E. Coli (PDB entry [[2pl1]])' scene=''> | |||
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'''PhoP-PhoQ''' is a two component regulatory system found in some gram-negative bacteria such as ''Escherichia coli''[http://en.wikipedia.org/wiki/Escherichia_coli], ''Salmonella enterica'' Typhi[http://en.wikipedia.org/wiki/Salmonella_enterica], and ''Yersinia pestis''[http://en.wikipedia.org/wiki/Yersinia_pestis]. In a classic two component regulatory system, there exists a sensor kinase and a response regulator<ref name=Hoch>PMID:10745001</ref>. In the phoP-phoQ system, phoQ acts as the sensor kinase and phoP acts as the response regulator. The purpose of this signal transduction system in bacteria is to modify cellular output in response to environmental signals. In response to particular environmental stimuli, such as a low [Mg<sup>2+</sup>], the sensor kinase, phoQ autophosphorylates. Phosphorylated phoQ then transphosphorylates the response regulator, phoP, which in turn binds DNA and modulates transcription.<ref name=Hoch>PMID:10745001</ref> For more details see [[PhoP Regulatory Domain]]. | '''PhoP-PhoQ''' is a two component regulatory system found in some gram-negative bacteria such as ''Escherichia coli''[http://en.wikipedia.org/wiki/Escherichia_coli], ''Salmonella enterica'' Typhi[http://en.wikipedia.org/wiki/Salmonella_enterica], and ''Yersinia pestis''[http://en.wikipedia.org/wiki/Yersinia_pestis]. In a classic two component regulatory system, there exists a sensor kinase and a response regulator<ref name=Hoch>PMID:10745001</ref>. In the phoP-phoQ system, phoQ acts as the sensor kinase and phoP acts as the response regulator. The purpose of this signal transduction system in bacteria is to modify cellular output in response to environmental signals. In response to particular environmental stimuli, such as a low [Mg<sup>2+</sup>], the sensor kinase, phoQ autophosphorylates. Phosphorylated phoQ then transphosphorylates the response regulator, phoP, which in turn binds DNA and modulates transcription.<ref name=Hoch>PMID:10745001</ref> For more details see [[PhoP Regulatory Domain]]. | ||
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===PhoP: The Response Regulator=== | ===PhoP: The Response Regulator=== | ||