4rid: Difference between revisions
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''' | ==Human FAN1 nuclease== | ||
<StructureSection load='4rid' size='340' side='right' caption='[[4rid]], [[Resolution|resolution]] 3.30Å' scene=''> | |||
The entry | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4rid]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RID OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RID FirstGlance]. <br> | |||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ri8|4ri8]], [[4ri9|4ri9]], [[4ria|4ria]], [[4rib|4rib]], [[4ric|4ric]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rid OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rid RCSB], [http://www.ebi.ac.uk/pdbsum/4rid PDBsum]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/FAN1_HUMAN FAN1_HUMAN]] Karyomegalic interstitial nephritis. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/FAN1_HUMAN FAN1_HUMAN]] Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5'-flaps and 5'-exonuclease activity: may act in concert with the 3'-flap-specific enzymes to unhook the ICL by cleaving the lagging-strand template.<ref>PMID:20603015</ref> <ref>PMID:20603016</ref> <ref>PMID:20603073</ref> <ref>PMID:20671156</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Pavletich, N P]] | |||
[[Category: Wang, R]] | |||
[[Category: Hydrolase]] | |||
[[Category: Nuclease]] | |||