Molecular Playground/DNA replication initiator DnaA: Difference between revisions
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DnaA function is regulated by different nucleotide binding state. In ATP bound state, DnaA can recognize more binding elements on the chromosome(called DnaA box), and initiate replication by unwinding specific region in the DNA and recruit DnaB helicase. However, after the ATP hydrolysis, DnaA-ADP becomes an inactive protein. This activity change was shown to be associated with its oligomeric assembly state. | DnaA function is regulated by different nucleotide binding state. In ATP bound state, DnaA can recognize more binding elements on the chromosome(called DnaA box), and initiate replication by unwinding specific region in the DNA and recruit DnaB helicase. However, after the ATP hydrolysis, DnaA-ADP becomes an inactive protein. This activity change was shown to be associated with its oligomeric assembly state. | ||
<Structure load='4u0g' size='400' frame='true' align='right' caption='test' scene='49/493690/Test/1' /> | |||
This is a <scene name='49/493690/Test/1'>test(residues 76-399)</scene>, which contains an <scene name='49/493690/Test/1'>ADP</scene> in it. | |||
<scene name='49/493690/Test/1'>This is a test molecule</scene> | <scene name='49/493690/Test/1'>This is a test molecule</scene> | ||
=== DnaA Monomer Structure === | === DnaA Monomer Structure === | ||