1lhs: Difference between revisions
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|PDB= 1lhs |SIZE=350|CAPTION= <scene name='initialview01'>1lhs</scene>, resolution 2.0Å | |PDB= 1lhs |SIZE=350|CAPTION= <scene name='initialview01'>1lhs</scene>, resolution 2.0Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN IX CONTAINING FE'>HEM</scene> | |LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lhs OCA], [http://www.ebi.ac.uk/pdbsum/1lhs PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lhs RCSB]</span> | |||
}} | }} | ||
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[[Category: Sanctis, G De.]] | [[Category: Sanctis, G De.]] | ||
[[Category: Tarricone, C.]] | [[Category: Tarricone, C.]] | ||
[[Category: oxygen storage]] | [[Category: oxygen storage]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:02:55 2008'' | ||
Revision as of 22:03, 30 March 2008
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| , resolution 2.0Å | |||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
LOGGERHEAD SEA TURTLE MYOGLOBIN (AQUO-MET)
OverviewOverview
The X-ray crystal structures of the aquo-met and cyano-met derivatives of the loggerhead sea turtle (Caretta caretta) myoglobin have been determined at 2.0 A resolution (R = 0.182, and 0.178, respectively). The results here reported, representing the first reptile globin solved by X-ray crystallography, have been analyzed in parallel with data for related monomeric hemoproteins, and indicate a strong overall structural similarity between the loggerhead sea turtle and mammalian myoglobins, reflected by the 63% amino acid identity of their primary structures. The root-mean-square deviation between the entire polypeptide backbones of loggerhead sea turtle and sperm whale myoglobins, after structure superposition, is 0.83 A. Upon cyanide binding to the protein distal site, the iron-bound water molecule present in the aquo-met form is displaced by the incoming ligand. Cyanide is oriented towards the inner part of the heme distal site forming a Fe-C-N angle of 133 degrees.
About this StructureAbout this Structure
1LHS is a Single protein structure of sequence from Caretta caretta. Full crystallographic information is available from OCA.
ReferenceReference
Reptile heme protein structure: X-ray crystallographic study of the aquo-met and cyano-met derivatives of the loggerhead sea turtle (Caretta caretta) myoglobin at 2.0 A resolution., Nardini M, Tarricone C, Rizzi M, Lania A, Desideri A, De Sanctis G, Coletta M, Petruzzelli R, Ascenzi P, Coda A, et al., J Mol Biol. 1995 Mar 31;247(3):459-65. PMID:7714901
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