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==Three-dimensional structure of the human transglutaminase 3 enzyme: binding of calcium ions change structure for activation== | ==Three-dimensional structure of the human transglutaminase 3 enzyme: binding of calcium ions change structure for activation== | ||
<StructureSection load='1l9m' size='340' side='right' caption='[[1l9m]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='1l9m' size='340' side='right' caption='[[1l9m]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l9m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l9m RCSB], [http://www.ebi.ac.uk/pdbsum/1l9m PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l9m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l9m RCSB], [http://www.ebi.ac.uk/pdbsum/1l9m PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/TGM3_HUMAN TGM3_HUMAN]] Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||