Arginine repressor

Arginine repressor (ArgR) is a prokaryotic repressor which regulates the arginine deiminase pathway. In this pathway, arginine is metabolized to form ammonia, CO2 and ATP. The ArgR releases the expression of the arginine deiminase pathway in the presence of arginine. The genes controlled by ArgR are not found in a single operon. While repressors are usually active as dimers, ArgR is a hexamer and binds to 2 palindromic DNA sites. The structure of ArgR shows a DNA-binding domain at the N-terminal and a C-terminal domain which contains the intersubunit interaction sites and the Arg binding site.

spinqualitylabelsall models Structure of arginine repressor hexamer complex with DNA and arginine (PDB entry 3laj) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of arginine repressor3D structures of arginine repressor

Updated on 17-November-2014

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• Arginine repressor
  • 1b4a – GsArgR – Geobacillus stearothermophilus
    
  • 1f9n – BsArgR – Bacillus subtilis
    
  • 3v4g – ArgR – Vibrio vulnificus
    
  • 3ere – MtArgR + DNA – Mycobacterium tuberculosis
    
  • 3fhz, 3laj – MtArgR + DNA + Arg
    
  • 3lap – MtArgR + DNA + canavanine
    
• Arginine repressor N terminal
  • 1aoy – EcArgR N terminal - Escherichia coli - NMR
    
  • 1b4b – BsArgR N terminal
    
  • 2p5l – BsArgR N terminal + DNA
    
• Arginine repressor C terminal
  • 1xxc – EcArgR C terminal
    
  • 2p5k – GsArgR C terminal
    
  • 3bue – MtArgR C terminal
    
  • 1xxa, 1xxb – EcArgR C terminal + Arg
    
  • 2p5m – BsArgR C terminal (mutant) + Arg
    
  • 2zfz, 3cag – MtArgR C terminal + Arg