1hbk: Difference between revisions
New page: left|200px<br /> <applet load="1hbk" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hbk, resolution 2.00Å" /> '''ACYL-COA BINDING PR... |
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==About this Structure== | ==About this Structure== | ||
1HBK is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]] with NI, COA and MYR as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HBK OCA]]. | 1HBK is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]] with NI, COA and MYR as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Sites: COA, MYR, NI1 and NI2. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HBK OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: fatty acid metabolism]] | [[Category: fatty acid metabolism]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:46:10 2007'' | ||
Revision as of 09:41, 30 October 2007
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ACYL-COA BINDING PROTEIN FROM PLASMODIUM FALCIPARUM
OverviewOverview
Acyl-CoA binding protein (ACBP) maintains a pool of fatty acyl-CoA, molecules in the cell and plays a role in fatty acid metabolism. The, biochemical properties of Plasmodium falciparum ACBP are described, together with the 2.0 A resolution crystal structures of a P. falciparum, ACBP-acyl-CoA complex and of bovine ACBP in two crystal forms. Overall, the bovine ACBP crystal structures are similar to the NMR structures, published previously; however, the bovine and parasite ACBP structures are, less similar. The parasite ACBP is shown to have a different, ligand-binding pocket, leading to an acyl-CoA binding specificity, different from that of bovine ACBP. Several non-conservative differences, in residues that interact with the ligand were identified between the, mammalian and parasite ... [(full description)]
About this StructureAbout this Structure
1HBK is a [Protein complex] structure of sequences from [Plasmodium falciparum] with NI, COA and MYR as [ligands]. Structure known Active Sites: COA, MYR, NI1 and NI2. Full crystallographic information is available from [OCA].
ReferenceReference
Binding site differences revealed by crystal structures of Plasmodium falciparum and bovine acyl-CoA binding protein., van Aalten DM, Milne KG, Zou JY, Kleywegt GJ, Bergfors T, Ferguson MA, Knudsen J, Jones TA, J Mol Biol. 2001 May 25;309(1):181-92. PMID:11491287
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