4qu8: Difference between revisions
No edit summary |
No edit summary |
||
| Line 9: | Line 9: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qu8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qu8 RCSB], [http://www.ebi.ac.uk/pdbsum/4qu8 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qu8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qu8 RCSB], [http://www.ebi.ac.uk/pdbsum/4qu8 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 22: | Line 24: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Caspase-3]] | [[Category: Caspase-3]] | ||
[[Category: Cade, C | [[Category: Cade, C]] | ||
[[Category: Clark, A C | [[Category: Clark, A C]] | ||
[[Category: MacKenzie, S H | [[Category: MacKenzie, S H]] | ||
[[Category: Swartz, P D | [[Category: Swartz, P D]] | ||
[[Category: Allosteric network]] | [[Category: Allosteric network]] | ||
[[Category: Hydrolase-hydrolase inhibitor complex]] | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||