4p4t: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p4t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p4t RCSB], [http://www.ebi.ac.uk/pdbsum/4p4t PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p4t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p4t RCSB], [http://www.ebi.ac.uk/pdbsum/4p4t PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/MX1_HUMAN MX1_HUMAN]] Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.<ref>PMID:20603636</ref> <ref>PMID:11880649</ref> <ref>PMID:15047845</ref> <ref>PMID:14752052</ref> <ref>PMID:15355513</ref> <ref>PMID:14687945</ref> <ref>PMID:15757897</ref> <ref>PMID:16413306</ref> <ref>PMID:16202617</ref> <ref>PMID:17374778</ref> <ref>PMID:18668195</ref> <ref>PMID:19109387</ref> <ref>PMID:21900240</ref> <ref>PMID:21992152</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Bulloch, E M | [[Category: Bulloch, E M]] | ||
[[Category: Kingston, R L | [[Category: Kingston, R L]] | ||
[[Category: McKelvie, S A | [[Category: McKelvie, S A]] | ||
[[Category: Rennie, M L | [[Category: Rennie, M L]] | ||
[[Category: Antiviral]] | [[Category: Antiviral]] | ||
[[Category: Antiviral protein-hydrolase complex]] | [[Category: Antiviral protein-hydrolase complex]] | ||