Rossmann fold: Difference between revisions
| Line 65: | Line 65: | ||
==Evolutionary origin of the βαβ fold == | ==Evolutionary origin of the βαβ fold == | ||
A myriad of proteins include the βαβ Rossmann fold. Many of these proteins can be grouped in a hierarchy of families based on their sequence similarities <ref>PMID:11514662</ref>,<ref>PMID:8749365</ref>,<ref>PMID:17658942</ref>. Yet, many of these families do not show any significant sequence homology across families. | A myriad of proteins include the βαβ Rossmann fold. Proteopedia includes a list of over 1,000 PDB structures with [[:Category:Rossmann fold | Rossmann fold]]. Many of these proteins can be grouped in a hierarchy of families based on their sequence similarities <ref>PMID:11514662</ref>,<ref>PMID:8749365</ref>,<ref>PMID:17658942</ref>. Yet, many of these families do not show any significant sequence homology across families. | ||
The observation that the βαβ structure and its consensus sequence is observed in many seemingly unrelated proteins raises the question whether the origin of the βαβ fold of all these proteins is a common ancestral sequence. Alternatively, there is also a possibility that this structure emerged in different proteins independently. | The observation that the βαβ structure and its consensus sequence is observed in many seemingly unrelated proteins raises the question whether the origin of the βαβ fold of all these proteins is a common ancestral sequence. Alternatively, there is also a possibility that this structure emerged in different proteins independently. | ||