1k66: Difference between revisions
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= AF309560 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1188 Tolypothrix sp. PCC 7601]) | |GENE= AF309560 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1188 Tolypothrix sp. PCC 7601]) | ||
|DOMAIN= | |||
|RELATEDENTRY=[[1k68|1K68]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k66 OCA], [http://www.ebi.ac.uk/pdbsum/1k66 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k66 RCSB]</span> | |||
}} | }} | ||
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[[Category: Marsac, N Tandeau de.]] | [[Category: Marsac, N Tandeau de.]] | ||
[[Category: Scheufler, C.]] | [[Category: Scheufler, C.]] | ||
[[Category: (beta/alpha)5]] | [[Category: (beta/alpha)5]] | ||
[[Category: apo-protein]] | [[Category: apo-protein]] | ||
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[[Category: response regulator]] | [[Category: response regulator]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:44:00 2008'' | ||
Revision as of 21:44, 30 March 2008
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| , resolution 1.75Å | |||||||
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| Ligands: | |||||||
| Gene: | AF309560 (Tolypothrix sp. PCC 7601) | ||||||
| Related: | 1K68
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of the Cyanobacterial Phytochrome Response Regulator, RcpB
OverviewOverview
The structures of two response regulators (RRs) from the cyanobacterium Calothrix PCC7601, RcpA and RcpB, were solved to 1.9- and 1.75-A resolution, respectively. RcpA was found in phosphorylated and RcpB in nonphosphorylated form. Both RRs are members of phytochrome-associated, light-sensing two-component signal transduction pathways, based on histidine kinase-mediated receptor autophosphorylation and phosphorelay to a RR. Despite the overall folding similarity to CheY-type RRs ((beta/alpha)(5)-motif), RcpA and RcpB form homodimers, irrespective of their phosphorylation state, giving insight into a signal transduction putatively different from that of other known RRs. Dimerization is accomplished by a C-terminal extension of the RR polypeptide chain, and the surface formed by H4, beta 5, and H5, which constitute a hydrophobic contact area with distinct interactions between residues of either subunit. Sequence alignments reveal that the identified dimerization motif is archetypal for phytochrome-associated RRs, making them a novel subgroup of CheY-type RRs. The protein structures of RcpA and RcpB are compared to the recently presented protein structure of Rcp1 from Synechocystis.
About this StructureAbout this Structure
1K66 is a Single protein structure of sequence from Tolypothrix sp. pcc 7601. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structures of two cyanobacterial response regulators in apo- and phosphorylated form reveal a novel dimerization motif of phytochrome-associated response regulators., Benda C, Scheufler C, Tandeau de Marsac N, Gartner W, Biophys J. 2004 Jul;87(1):476-87. PMID:15240481
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