3afa: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3afa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3afa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3afa RCSB], [http://www.ebi.ac.uk/pdbsum/3afa PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3afa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3afa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3afa RCSB], [http://www.ebi.ac.uk/pdbsum/3afa PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
==See Also== | |||
*[[Histone|Histone]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Kagawa, W | [[Category: Kagawa, W]] | ||
[[Category: Kimura, H | [[Category: Kimura, H]] | ||
[[Category: Koichiro, K | [[Category: Koichiro, K]] | ||
[[Category: Kurumizaka, H | [[Category: Kurumizaka, H]] | ||
[[Category: Osakabe, A | [[Category: Osakabe, A]] | ||
[[Category: Shiga, T | [[Category: Shiga, T]] | ||
[[Category: Tachiwana, H | [[Category: Tachiwana, H]] | ||
[[Category: Antibiotic]] | [[Category: Antibiotic]] | ||
[[Category: Antimicrobial]] | [[Category: Antimicrobial]] | ||