1k09: Difference between revisions
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|PDB= 1k09 |SIZE=350|CAPTION= <scene name='initialview01'>1k09</scene> | |PDB= 1k09 |SIZE=350|CAPTION= <scene name='initialview01'>1k09</scene> | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=NH2:AMINO GROUP'>NH2</scene> | |LIGAND= <scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=CLG:2-AMINO-6-[2-(2-AMINOOXY-ACETYLAMINO)-ACETYLAMINO]-HEXANOIC+ACID'>CLG</scene>, <scene name='pdbligand=CLH:2-AMINO-6-[2-(2-OXO-ACETYLAMINO)-ACETYLAMINO]-HEXANOIC+ACID'>CLH</scene>, <scene name='pdbligand=MPT:BETA-MERCAPTOPROPIONIC+ACID'>MPT</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k09 OCA], [http://www.ebi.ac.uk/pdbsum/1k09 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k09 RCSB]</span> | |||
}} | }} | ||
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[[Category: Carulla, N.]] | [[Category: Carulla, N.]] | ||
[[Category: Woodward, C.]] | [[Category: Woodward, C.]] | ||
[[Category: four-stranded antiparallel beta-sheet]] | [[Category: four-stranded antiparallel beta-sheet]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:41:31 2008'' | ||
Revision as of 21:41, 30 March 2008
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| Ligands: | , , , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution structure of BetaCore, A Designed Water Soluble Four-Stranded Antiparallel b-sheet Protein
OverviewOverview
BetaCore is a designed approximately 50-residue protein in which two BPTI-derived core modules, CM I and CM II, are connected by a 22-atom cross-link. At low temperature and pH 3, homo- and heteronuclear NMR data report a dominant folded ('f') conformation with well-dispersed chemical shifts, i, i+1 periodicity, numerous long-range NOEs, and slowed amide hydrogen isotope exchange patterns that is a four-stranded antiparallel beta-sheet with nonsymmetrical and specific association of CM I and CM II. BetaCore 'f' conformations undergo reversible, global, moderately cooperative, non-two-state thermal transitions to an equilibrium ensemble of unfolded 'u' conformations. There is a significant energy barrier between 'f' and 'u' conformations. This is the first designed four-stranded antiparallel beta-sheet that folds in water.
About this StructureAbout this Structure
1K09 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
ReferenceReference
BetaCore, a designed water soluble four-stranded antiparallel beta-sheet protein., Carulla N, Woodward C, Barany G, Protein Sci. 2002 Jun;11(6):1539-51. PMID:12021452
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