2xs1: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xs1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xs1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xs1 RCSB], [http://www.ebi.ac.uk/pdbsum/2xs1 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xs1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xs1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xs1 RCSB], [http://www.ebi.ac.uk/pdbsum/2xs1 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/PDC6I_HUMAN PDC6I_HUMAN]] Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Appears to be an adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function implies the interaction with CHMP4B. May play a role in the regulation of both apoptosis and cell proliferation.<ref>PMID:14505569</ref> <ref>PMID:14505570</ref> <ref>PMID:14739459</ref> <ref>PMID:17853893</ref> <ref>PMID:17428861</ref> <ref>PMID:17556548</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Hill, C P | [[Category: Hill, C P]] | ||
[[Category: Landesman, M | [[Category: Landesman, M]] | ||
[[Category: Robinson, H | [[Category: Robinson, H]] | ||
[[Category: Sundquist, W I | [[Category: Sundquist, W I]] | ||
[[Category: Zhai, Q | [[Category: Zhai, Q]] | ||
[[Category: Cell cycle]] | [[Category: Cell cycle]] | ||
[[Category: Protein transport-viral protein complex]] | [[Category: Protein transport-viral protein complex]] | ||