2y6c: Difference between revisions

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y6c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y6c RCSB], [http://www.ebi.ac.uk/pdbsum/2y6c PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y6c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y6c RCSB], [http://www.ebi.ac.uk/pdbsum/2y6c PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/MMP7_HUMAN MMP7_HUMAN]] Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.<ref>PMID:2550050</ref> 


==See Also==
==See Also==
*[[Matrix metalloproteinase|Matrix metalloproteinase]]
*[[Matrix metalloproteinase|Matrix metalloproteinase]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Matrilysin]]
[[Category: Matrilysin]]
[[Category: Edman, K.]]
[[Category: Edman, K]]
[[Category: Furber, M.]]
[[Category: Furber, M]]
[[Category: Hemsley, P.]]
[[Category: Hemsley, P]]
[[Category: Johansson, C.]]
[[Category: Johansson, C]]
[[Category: Pairaudeau, G.]]
[[Category: Pairaudeau, G]]
[[Category: Petersen, J.]]
[[Category: Petersen, J]]
[[Category: Stocks, M.]]
[[Category: Stocks, M]]
[[Category: Tervo, A.]]
[[Category: Tervo, A]]
[[Category: Ward, A.]]
[[Category: Ward, A]]
[[Category: Wells, E.]]
[[Category: Wells, E]]
[[Category: Wissler, L.]]
[[Category: Wissler, L]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]

Revision as of 05:27, 25 December 2014

THE DISCOVERY OF MMP7 INHIBITORS EXPLOITING A NOVEL SELECTIVITY TRIGGERTHE DISCOVERY OF MMP7 INHIBITORS EXPLOITING A NOVEL SELECTIVITY TRIGGER

Structural highlights

2y6c is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , ,
Activity:Matrilysin, with EC number 3.4.24.23
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[MMP7_HUMAN] Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.[1]

See Also

References

  1. Quantin B, Murphy G, Breathnach R. Pump-1 cDNA codes for a protein with characteristics similar to those of classical collagenase family members. Biochemistry. 1989 Jun 27;28(13):5327-34. PMID:2550050

2y6c, resolution 1.70Å

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