4rg2: Difference between revisions

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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C.]]
[[Category: Bountra, C]]
[[Category: Brown, P J.]]
[[Category: Brown, P J]]
[[Category: Dong, A.]]
[[Category: Dong, A]]
[[Category: Edwards, A M.]]
[[Category: Edwards, A M]]
[[Category: Frye, S.]]
[[Category: Frye, S]]
[[Category: James, L.]]
[[Category: James, L]]
[[Category: Mader, P.]]
[[Category: Mader, P]]
[[Category: Perfetti, M.]]
[[Category: Perfetti, M]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Structural genomic]]
[[Category: Tempel, W.]]
[[Category: Tempel, W]]
[[Category: 53bp1 tudor]]
[[Category: 53bp1 tudor]]
[[Category: Sgc]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
[[Category: Transcription]]
[[Category: Transcription]]

Revision as of 09:51, 22 January 2015

Tudor Domain of Tumor suppressor p53BP1 with small molecule ligandTudor Domain of Tumor suppressor p53BP1 with small molecule ligand

Structural highlights

4rg2 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Resources:FirstGlance, OCA, RCSB, PDBsum

Disease

[TP53B_HUMAN] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.

Function

[TP53B_HUMAN] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.[1] [2]

References

  1. ↑ Wang B, Matsuoka S, Carpenter PB, Elledge SJ. 53BP1, a mediator of the DNA damage checkpoint. Science. 2002 Nov 15;298(5597):1435-8. Epub 2002 Oct 3. PMID:12364621 doi:10.1126/science.1076182
  2. ↑ Botuyan MV, Lee J, Ward IM, Kim JE, Thompson JR, Chen J, Mer G. Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell. 2006 Dec 29;127(7):1361-73. PMID:17190600 doi:10.1016/j.cell.2006.10.043

4rg2, resolution 1.50Å

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OCA
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