1jmu: Difference between revisions
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|PDB= 1jmu |SIZE=350|CAPTION= <scene name='initialview01'>1jmu</scene>, resolution 2.80Å | |PDB= 1jmu |SIZE=350|CAPTION= <scene name='initialview01'>1jmu</scene>, resolution 2.80Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand= | |LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= M2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10891 Reovirus sp.]), S4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10891 Reovirus sp.]) | |GENE= M2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10891 Reovirus sp.]), S4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10891 Reovirus sp.]) | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jmu OCA], [http://www.ebi.ac.uk/pdbsum/1jmu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jmu RCSB]</span> | |||
}} | }} | ||
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[[Category: Liemann, S.]] | [[Category: Liemann, S.]] | ||
[[Category: Nibert, M L.]] | [[Category: Nibert, M L.]] | ||
[[Category: jelly roll]] | [[Category: jelly roll]] | ||
[[Category: protein-protein complex]] | [[Category: protein-protein complex]] | ||
[[Category: zinc finger]] | [[Category: zinc finger]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:35:53 2008'' | ||
Revision as of 21:35, 30 March 2008
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| , resolution 2.80Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , , | ||||||
| Gene: | M2 (Reovirus sp.), S4 (Reovirus sp.) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of the Reovirus mu1/sigma3 Complex
OverviewOverview
Cell entry by nonenveloped animal viruses requires membrane penetration without membrane fusion. The reovirus penetration agent is the outer-capsid protein, Mu1. The structure of Mu1, complexed with its "protector" protein, Sigma3, and the fit of this Mu1(3)Sigma3(3) heterohexameric complex into the cryoEM image of an intact virion, reveal molecular events essential for viral penetration. Autolytic cleavage divides Mu1 into myristoylated Mu1N and Mu1C. A long hydrophobic pocket can receive the myristoyl group. Dissociation of Mu1N, linked to a major conformational change of the entire Mu1 trimer, must precede myristoyl-group insertion into the cellular membrane. A myristoyl switch, coupling exposure of the fatty acid chain, autolytic cleavage of Mu1N, and long-range molecular rearrangement of Mu1C, thus appears to be part of the penetration mechanism.
About this StructureAbout this Structure
1JMU is a Protein complex structure of sequences from Reovirus sp.. Full crystallographic information is available from OCA.
ReferenceReference
Structure of the reovirus membrane-penetration protein, Mu1, in a complex with is protector protein, Sigma3., Liemann S, Chandran K, Baker TS, Nibert ML, Harrison SC, Cell. 2002 Jan 25;108(2):283-95. PMID:11832217
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