VP24: Difference between revisions
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There are a few structural characteristics only found in the Ebola viruses. At the top of the pyramidal domain, there are α helices present which are thought to interact with the α karyopherin(1). An α helix formed by the N-terminus runs from the top of the "pyramid" to another nearby VP24, where it binds to one of the pockets located underneath the "pyramid"(1). | There are a few structural characteristics only found in the Ebola viruses. At the top of the pyramidal domain, there are α helices present which are thought to interact with the α karyopherin(1). An α helix formed by the N-terminus runs from the top of the "pyramid" to another nearby VP24, where it binds to one of the pockets located underneath the "pyramid"(1). | ||
<scene name='60/602719/Marburg_vp24_domain/1'>Marburg | <scene name='60/602719/Marburg_vp24_domain/1'>Marburg Domain</scene> | ||
The Marburg domain has two beta strands present that stick out from the structure(1). The Marburg VP24 doesn't use an alpha helix to bind to another VP24 like the Ebola VP24(1). Instead, it uses a flexible strand that binds to a groove of a close-by VP24(1). | The Marburg domain has two beta strands present that stick out from the structure(1). The Marburg VP24 doesn't use an alpha helix to bind to another VP24 like the Ebola VP24(1). Instead, it uses a flexible strand that binds to a groove of a close-by VP24(1). | ||