VP24: Difference between revisions
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In a normal immune response interferons (IFN) are produced to alert surrounding cells to the presence of a pathogen. This response activates STAT1 by phosphorylation. STAT1 is a transcription factor that increases production of immune fighting genes in cells, STAT1 is brought to the nucleus by karyopherin α proteins. Ebola protein VP24 | In a normal immune response interferons (IFN) are produced to alert surrounding cells to the presence of a pathogen. This response activates STAT1 by phosphorylation. STAT1 is a transcription factor that increases production of immune fighting genes in cells, STAT1 is brought to the nucleus by karyopherin α proteins. Ebola protein VP24 | ||
<scene name='60/602719/Vp24_bound_to_karyopherin_a5/1'>binds to karyopherin</scene> α1, α5, and α6, making it unable to transport the P-STAT1 to the nucleus. As a result, the immune response in cells is then greatly weakened. | <scene name='60/602719/Vp24_bound_to_karyopherin_a5/1'>binds to karyopherin</scene> α1, α5, and α6, making it unable to transport the P-STAT1 to the nucleus. As a result, the immune response in cells is then greatly weakened. | ||
'''Marburg''' | '''Marburg''' | ||
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The Marburg domain has two beta strands present that stick out from the structure. Another difference is that the Marburg VP24 doesn't use an alpha helix to bind to another VP24. Instead, it uses a flexible strand that binds to a groove, not a pocket, found in another VP24. | The Marburg domain has two beta strands present that stick out from the structure. Another difference is that the Marburg VP24 doesn't use an alpha helix to bind to another VP24. Instead, it uses a flexible strand that binds to a groove, not a pocket, found in another VP24. | ||
</StructureSection> | |||
== References == | |||
<references/> | <references/> | ||