VP24: Difference between revisions
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<StructureSection load='4D9O' size='340' side='right' caption='VP24 from the Reston Ebola Virus' scene=''> | <StructureSection load='4D9O' size='340' side='right' caption='VP24 from the Reston Ebola Virus' scene=''> | ||
== Introduction == | == Introduction == | ||
VP24 is a protein present in the Ebola and Marburg viruses, both of which are members of ''Filoviridae'' family. Presently there are five strains of Ebola: Sudan, Reston, Zire, Bundibugyo, and Taï Forest, each with minor differences in VP24 sequences(3) | VP24 is a protein present in the Ebola and Marburg viruses, both of which are members of ''Filoviridae'' family. Presently there are five strains of Ebola: Sudan, Reston, Zire, Bundibugyo, and Taï Forest, each with minor differences in VP24 sequences(3). | ||
== Function == | == Function == | ||
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'''Ebola''' | '''Ebola''' | ||
In a normal immune response interferons (IFN) are produced to alert surrounding cells to the presence of a pathogen. This response activates STAT1 by phosphorylation. STAT1 is a transcription factor that increases production of immune fighting genes in cells, STAT1 is brought to the nucleus by karyopherin α proteins. Ebola protein VP24 binds to karyopherin α1 | In a normal immune response interferons (IFN) are produced to alert surrounding cells to the presence of a pathogen. This response activates STAT1 by phosphorylation. STAT1 is a transcription factor that increases production of immune fighting genes in cells, STAT1 is brought to the nucleus by karyopherin α proteins. Ebola protein VP24 | ||
<scene name='60/602719/Vp24_bound_to_karyopherin_a5/1'> binds to karyopherin α5 </scene> | |||
</StructureSection> α1, and α6, making it unable to transport the P-STAT1 to the nucleus. As a result, the immune response in cells is then greatly weakened. | |||
'''Marburg''' | '''Marburg''' | ||
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<scene name='60/602719/Chain_b/1'>Chain B</scene> | <scene name='60/602719/Chain_b/1'>Chain B</scene> | ||
== References == | == References == | ||
<references/> | <references/> | ||