2zao: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zao FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zao OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zao RCSB], [http://www.ebi.ac.uk/pdbsum/2zao PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zao FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zao OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zao RCSB], [http://www.ebi.ac.uk/pdbsum/2zao PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/VPS4B_MOUSE VPS4B_MOUSE]] Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (By similarity).<ref>PMID:10393249</ref> <ref>PMID:10679028</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Lk3 transgenic mice]] | [[Category: Lk3 transgenic mice]] | ||
[[Category: Inoue, M | [[Category: Inoue, M]] | ||
[[Category: Kamikubo, H | [[Category: Kamikubo, H]] | ||
[[Category: Kataoka, M | [[Category: Kataoka, M]] | ||
[[Category: Kato, R | [[Category: Kato, R]] | ||
[[Category: Kawasaki, M | [[Category: Kawasaki, M]] | ||
[[Category: Wakatsuki, S | [[Category: Wakatsuki, S]] | ||
[[Category: Yoshimori, T | [[Category: Yoshimori, T]] | ||
[[Category: Aaa atpase]] | [[Category: Aaa atpase]] | ||
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||