1jb3: Difference between revisions
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jb3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jb3 OCA], [http://www.ebi.ac.uk/pdbsum/1jb3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jb3 RCSB]</span> | |||
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:31:10 2008'' | ||
Revision as of 21:31, 30 March 2008
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| , resolution 1.60Å | |||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
The Laminin-Binding Domain of Agrin is structurally related to N-TIMP-1
OverviewOverview
Agrin is the key organizer of postsynaptic differentiation at the neuromuscular junction. This organization activity requires the binding of agrin to the synaptic basal lamina. Binding is conferred by the N-terminal agrin (NtA) domain, which mediates a high-affinity interaction with the coiled coil domain of laminins. Here, we report the crystal structure of chicken NtA at 1.6 A resolution. The structure reveals that NtA harbors an oligosaccharide/oligonucleotide-binding fold with several possible sites for the interaction with different ligands. A high structural similarity of NtA with the protease inhibition domain in tissue inhibitor of metalloproteinases-1 (TIMP-1) supports the idea of additional functions of agrin besides synaptogenic activity.
About this StructureAbout this Structure
1JB3 is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.
ReferenceReference
The laminin-binding domain of agrin is structurally related to N-TIMP-1., Stetefeld J, Jenny M, Schulthess T, Landwehr R, Schumacher B, Frank S, Ruegg MA, Engel J, Kammerer RA, Nat Struct Biol. 2001 Aug;8(8):705-9. PMID:11473262
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