3lyr: Difference between revisions
No edit summary |
No edit summary |
||
| Line 8: | Line 8: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lyr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lyr RCSB], [http://www.ebi.ac.uk/pdbsum/3lyr PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lyr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lyr RCSB], [http://www.ebi.ac.uk/pdbsum/3lyr PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/COE1_HUMAN COE1_HUMAN]] Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity). | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 31: | Line 33: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Arrowsmith, C H | [[Category: Arrowsmith, C H]] | ||
[[Category: Berg, S Van Den | [[Category: Berg, S Van Den]] | ||
[[Category: Berglund, H | [[Category: Berglund, H]] | ||
[[Category: Bountra, C | [[Category: Bountra, C]] | ||
[[Category: Collins, R | [[Category: Collins, R]] | ||
[[Category: Edwards, A M | [[Category: Edwards, A M]] | ||
[[Category: Flodin, S | [[Category: Flodin, S]] | ||
[[Category: Flores, A | [[Category: Flores, A]] | ||
[[Category: Graslund, S | [[Category: Graslund, S]] | ||
[[Category: Hammarstrom, M | [[Category: Hammarstrom, M]] | ||
[[Category: Johansson, I | [[Category: Johansson, I]] | ||
[[Category: Karlberg, T | [[Category: Karlberg, T]] | ||
[[Category: Kotenyova, T | [[Category: Kotenyova, T]] | ||
[[Category: Kraulis, P | [[Category: Kraulis, P]] | ||
[[Category: Markova, N | [[Category: Markova, N]] | ||
[[Category: Moche, M | [[Category: Moche, M]] | ||
[[Category: Nordlund, P | [[Category: Nordlund, P]] | ||
[[Category: Nyman, T | [[Category: Nyman, T]] | ||
[[Category: Persson, C | [[Category: Persson, C]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Schuler, H | [[Category: Schuler, H]] | ||
[[Category: Schutz, P | [[Category: Schutz, P]] | ||
[[Category: Siponen, M I | [[Category: Siponen, M I]] | ||
[[Category: Svensson, L | [[Category: Svensson, L]] | ||
[[Category: Thorsell, A G | [[Category: Thorsell, A G]] | ||
[[Category: Tresaugues, L | [[Category: Tresaugues, L]] | ||
[[Category: Wahlberg, E | [[Category: Wahlberg, E]] | ||
[[Category: Weigelt, J | [[Category: Weigelt, J]] | ||
[[Category: Welin, M | [[Category: Welin, M]] | ||
[[Category: Wisniewska, M | [[Category: Wisniewska, M]] | ||
[[Category: Activator]] | [[Category: Activator]] | ||
[[Category: Developmental protein]] | [[Category: Developmental protein]] | ||
| Line 67: | Line 69: | ||
[[Category: Nucleus]] | [[Category: Nucleus]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
[[Category: Transcription activator]] | [[Category: Transcription activator]] | ||
[[Category: Transcription regulation]] | [[Category: Transcription regulation]] | ||
[[Category: Zinc-finger]] | [[Category: Zinc-finger]] | ||
Revision as of 11:11, 24 December 2014
Human Early B-cell Factor 1 (EBF1) DNA-binding domainHuman Early B-cell Factor 1 (EBF1) DNA-binding domain
Structural highlights
Function[COE1_HUMAN] Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedThe early B-cell factor (EBF) transcription factors are central regulators of development in several organs and tissues. This protein family shows low sequence similarity to other protein families, which is why structural information for the functional domains of these proteins is crucial to understand their biochemical features. We have used a modular approach to determine the crystal structures of the structured domains in the EBF family. The DNA binding domain reveals a striking resemblance to the DNA binding domains of the Rel homology superfamily of transcription factors but contains a unique zinc binding structure, termed zinc knuckle. Further the EBF proteins contain an IPT/TIG domain and an atypical helix-loop-helix domain with a novel type of dimerization motif. The data presented here provide insights into unique structural features of the EBF proteins and open possibilities for detailed molecular investigations of this important transcription factor family. Structural determination of functional domains in early B-cell factor (EBF) family of transcription factors reveals similarities to Rel DNA-binding proteins and a novel dimerization motif.,Siponen MI, Wisniewska M, Lehtio L, Johansson I, Svensson L, Raszewski G, Nilsson L, Sigvardsson M, Berglund H J Biol Chem. 2010 Aug 20;285(34):25875-9. Epub 2010 Jun 30. PMID:20592035[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
|
| ||||||||||||||||||||
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Human
- Arrowsmith, C H
- Berg, S Van Den
- Berglund, H
- Bountra, C
- Collins, R
- Edwards, A M
- Flodin, S
- Flores, A
- Graslund, S
- Hammarstrom, M
- Johansson, I
- Karlberg, T
- Kotenyova, T
- Kraulis, P
- Markova, N
- Moche, M
- Nordlund, P
- Nyman, T
- Persson, C
- Structural genomic
- Schuler, H
- Schutz, P
- Siponen, M I
- Svensson, L
- Thorsell, A G
- Tresaugues, L
- Wahlberg, E
- Weigelt, J
- Welin, M
- Wisniewska, M
- Activator
- Developmental protein
- Dna-binding
- Metal-binding
- Nucleus
- Sgc
- Transcription
- Transcription activator
- Transcription regulation
- Zinc-finger