1zdk: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1zdk]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacterio_phage_ms2 Enterobacterio phage ms2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZDK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZDK FirstGlance]. <br> | <table><tr><td colspan='2'>[[1zdk]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacterio_phage_ms2 Enterobacterio phage ms2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZDK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZDK FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zdk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zdk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zdk RCSB], [http://www.ebi.ac.uk/pdbsum/1zdk PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zdk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zdk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zdk RCSB], [http://www.ebi.ac.uk/pdbsum/1zdk PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/COAT_BPMS2 COAT_BPMS2]] Forms the phage shell; binds to the phage RNA. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Enterobacterio phage ms2]] | [[Category: Enterobacterio phage ms2]] | ||
[[Category: Grahn, E | [[Category: Grahn, E]] | ||
[[Category: Liljas, L | [[Category: Liljas, L]] | ||
[[Category: Stonehouse, N J | [[Category: Stonehouse, N J]] | ||
[[Category: Valegard, K | [[Category: Valegard, K]] | ||
[[Category: Vandenworm, S | [[Category: Vandenworm, S]] | ||
[[Category: Coat protein]] | [[Category: Coat protein]] | ||
[[Category: Icosahedral virus]] | [[Category: Icosahedral virus]] | ||
Revision as of 14:20, 25 December 2014
STRUCTURE OF BACTERIOPHAGE COAT PROTEIN-LOOP RNA COMPLEXSTRUCTURE OF BACTERIOPHAGE COAT PROTEIN-LOOP RNA COMPLEX
Structural highlights
Function[COAT_BPMS2] Forms the phage shell; binds to the phage RNA. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedThe coat protein of bacteriophage MS2 is known to bind specifically to an RNA hairpin formed within the MS2 genome. Structurally this hairpin is built up by an RNA double helix interrupted by one unpaired nucleotide and closed by a four-nucleotide loop. We have performed crystallographic studies of complexes between MS2 coat protein capsids and four RNA hairpin variants in order to evaluate the minimal requirements for tight binding to the coat protein and to obtain more information about the three-dimensional structure of these hairpins. An RNA fragment including the four loop nucleotides and a two-base-pair stem but without the unpaired nucleotide is sufficient for binding to the coat protein shell under the conditions used in this study. In contrast, an RNA fragment containing a stem with the unpaired nucleotide but missing the loop nucleotides does not bind to the protein shell. Crystallographic studies of RNA hairpins in complexes with recombinant MS2 capsids: implications for binding requirements.,Grahn E, Stonehouse NJ, Murray JB, van den Worm S, Valegard K, Fridborg K, Stockley PG, Liljas L RNA. 1999 Jan;5(1):131-8. PMID:9917072[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References |
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