2wdc: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2wdc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WDC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WDC FirstGlance]. <br> | <table><tr><td colspan='2'>[[2wdc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WDC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WDC FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=TBU:TERTIARY-BUTYL+ALCOHOL'>TBU</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=TBU:TERTIARY-BUTYL+ALCOHOL'>TBU</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2wdd|2wdd]], [[2wde|2wde]], [[2wdf|2wdf]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2wdd|2wdd]], [[2wde|2wde]], [[2wdf|2wdf]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.12.2.1 3.12.2.1] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.12.2.1 3.12.2.1] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wdc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wdc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wdc RCSB], [http://www.ebi.ac.uk/pdbsum/2wdc PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wdc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wdc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wdc RCSB], [http://www.ebi.ac.uk/pdbsum/2wdc PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Thermus thermophilus]] | [[Category: Thermus thermophilus]] | ||
[[Category: Antrobus, R | [[Category: Antrobus, R]] | ||
[[Category: Berks, B C | [[Category: Berks, B C]] | ||
[[Category: Garman, E F | [[Category: Garman, E F]] | ||
[[Category: Lea, S M | [[Category: Lea, S M]] | ||
[[Category: Leath, K J | [[Category: Leath, K J]] | ||
[[Category: Roversi, P | [[Category: Roversi, P]] | ||
[[Category: Sauve, V | [[Category: Sauve, V]] | ||
[[Category: Cys s-thiosulfonate]] | [[Category: Cys s-thiosulfonate]] | ||
[[Category: Sox]] | [[Category: Sox]] | ||
[[Category: Soxb]] | [[Category: Soxb]] | ||
[[Category: Sulfur oxidation pathway]] | [[Category: Sulfur oxidation pathway]] | ||
[[Category: Sulfur-sulfur hydrolysis]] | [[Category: Sulfur-sulfur hydrolysis]] | ||
Revision as of 12:01, 20 January 2015
TERMUS THERMOPHILUS SULFATE THIOHYDROLASE SOXB IN COMPLEX WITH GLYCEROLTERMUS THERMOPHILUS SULFATE THIOHYDROLASE SOXB IN COMPLEX WITH GLYCEROL
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedSoxB is an essential component of the bacterial Sox sulfur oxidation pathway. SoxB contains a di-manganese(II) site and is proposed to catalyze the release of sulfate from a protein-bound cysteine S-thiosulfonate. A direct assay for SoxB activity is described. The structure of recombinant Thermus thermophilus SoxB was determined by x-ray crystallography to a resolution of 1.5 A. Structures were also determined for SoxB in complex with the substrate analogue thiosulfate and in complex with the product sulfate. A mechanistic model for SoxB is proposed based on these structures. Mechanism for the hydrolysis of a sulfur-sulfur bond based on the crystal structure of the thiosulfohydrolase SoxB.,Sauve V, Roversi P, Leath KJ, Garman EF, Antrobus R, Lea SM, Berks BC J Biol Chem. 2009 Aug 7;284(32):21707-18. Epub 2009 Jun 16. PMID:19535341[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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