2v2w

T CELL CROSS-REACTIVITY AND CONFORMATIONAL CHANGES DURING TCR ENGAGEMENTT CELL CROSS-REACTIVITY AND CONFORMATIONAL CHANGES DURING TCR ENGAGEMENT

Structural highlights 2v2w is a 6 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 2bsu. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 1akj, 1ao7, 1aqd, 1b0g, 1b0r, 1bd2, 1duy, 1duz, 1eey, 1eez, 1hhg, 1hhh, 1hhi, 1hhj, 1hhk, 1hla, 1i1f, 1i1y, 1i4f, 1i7r, 1i7t, 1i7u, 1im3, 1jf1, 1jht, 1lp9, 1oga, 1p7q, 1qew, 1qr1, 1qrn, 1qse, 1qsf, 1s8d, 1s9w, 1s9x, 1s9y, 1t1w, 1t1x, 1t1y, 1t1z, 1t20, 1t21, 1t22, 1tvb, 1tvh, 1ur7, 2av1, 2av7, 2bnq, 2bnr, 2bsu, 2bsv, 2c7u, 2clr, 2gj6, 2jcc, 2uwe, 3hla, 1a1m, 1a1n, 1a1o, 1a6z, 1a9b, 1a9e, 1agb, 1agc, 1agd, 1age, 1agf, 1c16, 1ce6, 1cg9, 1de4, 1e27, 1e28, 1efx, 1exu, 1gzp, 1gzq, 1hsa, 1hsb, 1im9, 1jgd, 1jge, 1jnj, 1k5n, 1kpr, 1ktl, 1lds, 1m05, 1m6o, 1mhe, 1mi5, 1n2r, 1of2, 1ogt, 1onq, 1py4, 1q94, 1qlf, 1qqd, 1qvo, 1r3h, 1sys, 1syv, 1tmc, 1uqs, 1uxs, 1uxw, 1vgk, 1w0v, 1w0w, 1w72, 1x7q, 1xh3, 1xr8, 1xr9, 1xz0, 1ydp, 1ypz, 1zs8, 1zsd, 1zt4, 2a83, 2ak4, 2axf, 2axg, 2bck, 2bsr, 2bss, 2bst, 2bvq, 2cii, 2cik, 2d31, 2esv, 2f74, 2f8o, 2h26, 2hjk, 2hjl, 2hla, 2v2x Resources: FirstGlance, OCA, RCSB, PDBsum Function [1A02_HUMAN] Involved in the presentation of foreign antigens to the immune system. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed All thymically selected T cells are inherently cross-reactive, yet many data indicate a fine specificity in antigen recognition, which enables virus escape from immune control by mutation in infections such as the human immunodeficiency virus (HIV). To address this paradox, we analyzed the fine specificity of T cells recognizing a human histocompatibility leukocyte antigen (HLA)-A2-restricted, strongly immunodominant, HIV gag epitope (SLFNTVATL). The majority of 171 variant peptides tested bound HLA-A2, but only one third were recognized. Surprisingly, one recognized variant (SLYNTVATL) showed marked differences in structure when bound to HLA-A2. T cell receptor (TCR) recognition of variants of these two peptides implied that they adopted the same conformation in the TCR-peptide-major histocompatibility complex (MHC) complex. However, the on-rate kinetics of TCR binding were identical, implying that conformational changes at the TCR-peptide-MHC binding interface occur after an initial permissive antigen contact. These findings have implications for the rational design of vaccines targeting viruses with unstable genomes. T cell cross-reactivity and conformational changes during TCR engagement.,Lee JK, Stewart-Jones G, Dong T, Harlos K, Di Gleria K, Dorrell L, Douek DC, van der Merwe PA, Jones EY, McMichael AJ J Exp Med. 2004 Dec 6;200(11):1455-66. PMID:15583017 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Beta-2 microglobulin Major histocompatibility complex

spinqualitylabelsall models 2v2w, resolution 1.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image