2a72: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2a72]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A72 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A72 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2a72]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A72 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A72 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a72 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2a72 RCSB], [http://www.ebi.ac.uk/pdbsum/2a72 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a72 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2a72 RCSB], [http://www.ebi.ac.uk/pdbsum/2a72 PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/RGS7_HUMAN RGS7_HUMAN]] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/GNG5 dimer. May play a role in synaptic vesicle exocytosis. May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations (By similarity). | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith, C | [[Category: Arrowsmith, C]] | ||
[[Category: Debreczeni, J | [[Category: Debreczeni, J]] | ||
[[Category: Delft, F von | [[Category: Delft, F von]] | ||
[[Category: Doyle, D A | [[Category: Doyle, D A]] | ||
[[Category: Edwards, A | [[Category: Edwards, A]] | ||
[[Category: Elkins, J M | [[Category: Elkins, J M]] | ||
[[Category: Gileadi, O | [[Category: Gileadi, O]] | ||
[[Category: Johansson, C | [[Category: Johansson, C]] | ||
[[Category: Phillips, C | [[Category: Phillips, C]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Schoch, G A | [[Category: Schoch, G A]] | ||
[[Category: Smee, C | [[Category: Smee, C]] | ||
[[Category: Sundstrom, M | [[Category: Sundstrom, M]] | ||
[[Category: Human rgs7]] | [[Category: Human rgs7]] | ||
[[Category: Regulator of g-protein signaling 7]] | [[Category: Regulator of g-protein signaling 7]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
[[Category: Signaling protein]] | [[Category: Signaling protein]] | ||