2bel: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2bel]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BEL FirstGlance]. <br> | <table><tr><td colspan='2'>[[2bel]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BEL FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CBO:CARBENOXOLONE'>CBO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CBO:CARBENOXOLONE'>CBO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xu7|1xu7]], [[1xu9|1xu9]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xu7|1xu7]], [[1xu9|1xu9]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/11-beta-hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/11-beta-hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bel OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bel RCSB], [http://www.ebi.ac.uk/pdbsum/2bel PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bel OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bel RCSB], [http://www.ebi.ac.uk/pdbsum/2bel PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: 11-beta-hydroxysteroid dehydrogenase]] | [[Category: 11-beta-hydroxysteroid dehydrogenase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Abrahmsen, L | [[Category: Abrahmsen, L]] | ||
[[Category: Arrowsmith, C | [[Category: Arrowsmith, C]] | ||
[[Category: Bray, J | [[Category: Bray, J]] | ||
[[Category: Debreczeni, J E | [[Category: Debreczeni, J E]] | ||
[[Category: Delft, F Von | [[Category: Delft, F Von]] | ||
[[Category: Edwards, A | [[Category: Edwards, A]] | ||
[[Category: Elleby, B | [[Category: Elleby, B]] | ||
[[Category: Kavanagh, K | [[Category: Kavanagh, K]] | ||
[[Category: Oppermann, U | [[Category: Oppermann, U]] | ||
[[Category: Sharma, S | [[Category: Sharma, S]] | ||
[[Category: Sundstrom, M | [[Category: Sundstrom, M]] | ||
[[Category: Svensson, S | [[Category: Svensson, S]] | ||
[[Category: Wu, X | [[Category: Wu, X]] | ||
[[Category: Drug target]] | [[Category: Drug target]] | ||
[[Category: Glucocorticoid activation]] | [[Category: Glucocorticoid activation]] | ||
Revision as of 11:53, 8 January 2015
STRUCTURE OF HUMAN 11-BETA-HYDROXYSTEROID DEHYDROGENASE IN COMPLEX WITH NADP AND CARBENOXOLONESTRUCTURE OF HUMAN 11-BETA-HYDROXYSTEROID DEHYDROGENASE IN COMPLEX WITH NADP AND CARBENOXOLONE
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- 11-beta-hydroxysteroid dehydrogenase
- Homo sapiens
- Abrahmsen, L
- Arrowsmith, C
- Bray, J
- Debreczeni, J E
- Delft, F Von
- Edwards, A
- Elleby, B
- Kavanagh, K
- Oppermann, U
- Sharma, S
- Sundstrom, M
- Svensson, S
- Wu, X
- Drug target
- Glucocorticoid activation
- Hormone metabolism
- Inhibitor
- Microsome
- Nadp
- Oxidoreductase
- Short-chain dehydrogenase/reductase
- Steroid metabolism