1vka: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1vka]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VKA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VKA FirstGlance]. <br>
<table><tr><td colspan='2'>[[1vka]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VKA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VKA FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAPRE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAPRE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vka OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vka RCSB], [http://www.ebi.ac.uk/pdbsum/1vka PDBsum], [http://www.topsan.org/Proteins/SECSG/1vka TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vka OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vka RCSB], [http://www.ebi.ac.uk/pdbsum/1vka PDBsum], [http://www.topsan.org/Proteins/SECSG/1vka TOPSAN]</span></td></tr>
<table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/MARE1_HUMAN MARE1_HUMAN]] Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.<ref>PMID:12388762</ref> <ref>PMID:21646404</ref> <ref>PMID:16109370</ref> <ref>PMID:19632184</ref> 
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Dailey, H A.]]
[[Category: Dailey, H A]]
[[Category: Dailey, T A.]]
[[Category: Dailey, T A]]
[[Category: Liu, Z J.]]
[[Category: Liu, Z J]]
[[Category: Mayer, M R.]]
[[Category: Mayer, M R]]
[[Category: Rose, J P.]]
[[Category: Rose, J P]]
[[Category: SECSG, Southeast Collaboratory for Structural Genomics.]]
[[Category: Structural genomic]]
[[Category: Schubot, F D.]]
[[Category: Schubot, F D]]
[[Category: Shah, A.]]
[[Category: Shah, A]]
[[Category: Tempel, W.]]
[[Category: Tempel, W]]
[[Category: Wang, B C.]]
[[Category: Wang, B C]]
[[Category: Homo sapien]]
[[Category: Homo sapien]]
[[Category: Protein structure initiative]]
[[Category: PSI, Protein structure initiative]]
[[Category: Psi]]
[[Category: Q15691]]
[[Category: Q15691]]
[[Category: Secsg]]
[[Category: Secsg]]
[[Category: Southeast collaboratory for structural genomic]]
[[Category: Structural genomic]]
[[Category: Unknown function]]
[[Category: Unknown function]]

Revision as of 05:56, 25 December 2014

Southeast Collaboratory for Structural Genomics: Hypothetical Human Protein Q15691 N-Terminal FragmentSoutheast Collaboratory for Structural Genomics: Hypothetical Human Protein Q15691 N-Terminal Fragment

Structural highlights

1vka is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:MAPRE1 (Homo sapiens)
Resources:FirstGlance, OCA, RCSB, PDBsum, TOPSAN

Function

[MARE1_HUMAN] Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.[1] [2] [3] [4]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Askham JM, Vaughan KT, Goodson HV, Morrison EE. Evidence that an interaction between EB1 and p150(Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosome. Mol Biol Cell. 2002 Oct;13(10):3627-45. PMID:12388762 doi:10.1091/mbc.E02-01-0061
  2. ↑ van der Vaart B, Manatschal C, Grigoriev I, Olieric V, Gouveia SM, Bjelic S, Demmers J, Vorobjev I, Hoogenraad CC, Steinmetz MO, Akhmanova A. SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase. J Cell Biol. 2011 Jun 13;193(6):1083-99. Epub 2011 Jun 6. PMID:21646404 doi:10.1083/jcb.201012179
  3. ↑ Hayashi I, Wilde A, Mal TK, Ikura M. Structural basis for the activation of microtubule assembly by the EB1 and p150Glued complex. Mol Cell. 2005 Aug 19;19(4):449-60. PMID:16109370 doi:10.1016/j.molcel.2005.06.034
  4. ↑ Honnappa S, Gouveia SM, Weisbrich A, Damberger FF, Bhavesh NS, Jawhari H, Grigoriev I, van Rijssel FJ, Buey RM, Lawera A, Jelesarov I, Winkler FK, Wuthrich K, Akhmanova A, Steinmetz MO. An EB1-binding motif acts as a microtubule tip localization signal. Cell. 2009 Jul 23;138(2):366-76. PMID:19632184 doi:S0092-8674(09)00638-2

1vka, resolution 1.60Å

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OCA
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