1z3q: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1z3q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Musa_acuminata Musa acuminata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z3Q FirstGlance]. <br> | <table><tr><td colspan='2'>[[1z3q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Musa_acuminata Musa acuminata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z3Q FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z3q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z3q RCSB], [http://www.ebi.ac.uk/pdbsum/1z3q PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z3q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z3q RCSB], [http://www.ebi.ac.uk/pdbsum/1z3q PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Musa acuminata]] | [[Category: Musa acuminata]] | ||
[[Category: Barre, A | [[Category: Barre, A]] | ||
[[Category: Damme, E J.M Van | [[Category: Damme, E J.M Van]] | ||
[[Category: Leone, P | [[Category: Leone, P]] | ||
[[Category: Menu-Bouaouiche, L | [[Category: Menu-Bouaouiche, L]] | ||
[[Category: Payan, F | [[Category: Payan, F]] | ||
[[Category: Peumans, W J | [[Category: Peumans, W J]] | ||
[[Category: Rouge, P | [[Category: Rouge, P]] | ||
[[Category: Roussel, A | [[Category: Roussel, A]] | ||
[[Category: Antifungal protein]] | [[Category: Antifungal protein]] | ||
[[Category: Beta sandwich]] | [[Category: Beta sandwich]] | ||
Revision as of 11:50, 8 January 2015
Resolution of the structure of the allergenic and antifungal banana fruit thaumatin-like protein at 1.7AResolution of the structure of the allergenic and antifungal banana fruit thaumatin-like protein at 1.7A
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedThe structure of a thaumatin-like protein from banana (Musa acuminata) fruit, an allergen with antifungal properties, was solved at 1.7-A-resolution, by X-ray crystallography. Though the banana protein exhibits a very similar overall fold as thaumatin it markedly differs from the sweet-tasting protein by the presence of a surface exposed electronegative cleft. Due to the presence of this electronegative cleft, the banana thaumatin-like protein (Ban-TLP) acquires a strong (local) electronegative character that eventually explains the observed antifungal activity. Our structural analysis also revealed the presence of conserved residues of exposed epitopic determinants that are presumably responsible for the allergenic properties of banana fruit towards susceptible individuals, and provided evidence that the Ban-TLP shares some structurally highly conserved IgE-binding epitopes with thaumatin-like proteins from fruits or pollen from other plants. In addition, some overlap was detected between the predicted IgE-binding epitopes of the Ban-TLP and IgE-binding epitopes previously identified in the mountain cedar Jun a 3 TLP aeroallergen. The presence of these common epitopes offers a molecular basis for the cross-reactivity between aeroallergens and fruit allergens. Resolution of the structure of the allergenic and antifungal banana fruit thaumatin-like protein at 1.7-A.,Leone P, Menu-Bouaouiche L, Peumans WJ, Payan F, Barre A, Roussel A, Van Damme EJ, Rouge P Biochimie. 2006 Jan;88(1):45-52. Epub 2005 Aug 8. PMID:16085352[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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