3gi9: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3gi9]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GI9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GI9 FirstGlance]. <br> | <table><tr><td colspan='2'>[[3gi9]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GI9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GI9 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3gi8|3gi8]], [[3gia|3gia]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3gi8|3gi8]], [[3gia|3gia]]</td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MJ0609 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 Methanocaldococcus jannaschii])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MJ0609 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 Methanocaldococcus jannaschii])</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gi9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gi9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gi9 RCSB], [http://www.ebi.ac.uk/pdbsum/3gi9 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gi9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gi9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gi9 RCSB], [http://www.ebi.ac.uk/pdbsum/3gi9 PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Methanocaldococcus jannaschii]] | [[Category: Methanocaldococcus jannaschii]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Goehring, A S | [[Category: Goehring, A S]] | ||
[[Category: Gouaux, E | [[Category: Gouaux, E]] | ||
[[Category: NYCOMPS, New York Consortium on Membrane Protein Structure | [[Category: NYCOMPS, New York Consortium on Membrane Protein Structure]] | ||
[[Category: Shaffer, P L | [[Category: Shaffer, P L]] | ||
[[Category: Shankaranarayanan, A | [[Category: Shankaranarayanan, A]] | ||
[[Category: Antibody]] | [[Category: Antibody]] | ||
[[Category: Cell membrane]] | [[Category: Cell membrane]] | ||
| Line 45: | Line 45: | ||
[[Category: New york consortium on membrane protein structure]] | [[Category: New york consortium on membrane protein structure]] | ||
[[Category: Nycomp]] | [[Category: Nycomp]] | ||
[[Category: Protein structure initiative | [[Category: PSI, Protein structure initiative]] | ||
[[Category: Structural genomic]] | [[Category: Structural genomic]] | ||
[[Category: Transmembrane]] | [[Category: Transmembrane]] | ||
[[Category: Transport protein]] | [[Category: Transport protein]] | ||
[[Category: Transporter]] | [[Category: Transporter]] | ||
Revision as of 12:50, 20 January 2015
Crystal Structure of ApcT Transporter Bound to 7F11 Monoclonal Fab FragmentCrystal Structure of ApcT Transporter Bound to 7F11 Monoclonal Fab Fragment
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedAmino acid, polyamine, and organocation (APC) transporters are secondary transporters that play essential roles in nutrient uptake, neurotransmitter recycling, ionic homeostasis, and regulation of cell volume. Here, we present the crystal structure of apo-ApcT, a proton-coupled broad-specificity amino acid transporter, at 2.35 A resolution. The structure contains 12 transmembrane helices, with the first 10 consisting of an inverted structural repeat of 5 transmembrane helices like LeuT. The ApcT structure reveals an inward-facing, apo state and an amine moiety of Lys158 located in a position equivalent to the Na2 ion of LeuT. We propose that Lys158 is central to proton-coupled transport and that the amine group serves the same functional role as the Na2 ion in LeuT, thus demonstrating common principles among proton- and sodium-coupled transporters. Structure and Mechanism of a Na+ Independent Amino Acid Transporter.,Shaffer PL, Goehring A, Shankaranarayanan A, Gouaux E Science. 2009 Jul 22. PMID:19608859[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences |
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- Methanocaldococcus jannaschii
- Mus musculus
- Goehring, A S
- Gouaux, E
- NYCOMPS, New York Consortium on Membrane Protein Structure
- Shaffer, P L
- Shankaranarayanan, A
- Antibody
- Cell membrane
- Membrane
- Membrane protein
- New york consortium on membrane protein structure
- Nycomp
- PSI, Protein structure initiative
- Structural genomic
- Transmembrane
- Transport protein
- Transporter