3g0c: Difference between revisions

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 == Structural highlights ==
 <table><tr><td colspan='2'>[[3g0c]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G0C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G0C FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=RUF:7-(2-CHLOROBENZYL)-1,3-DIMETHYL-8-PIPERAZIN-1-YL-3,7-DIHYDRO-1H-PURINE-2,6-DIONE'>RUF</scene><br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=RUF:7-(2-CHLOROBENZYL)-1,3-DIMETHYL-8-PIPERAZIN-1-YL-3,7-DIHYDRO-1H-PURINE-2,6-DIONE'>RUF</scene></td></tr>
-<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3g0b|3g0b]], [[3g0d|3g0d]], [[3g0g|3g0g]]</td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3g0b|3g0b]], [[3g0d|3g0d]], [[3g0g|3g0g]]</td></tr>
-<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADCP2, CD26, DPP4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADCP2, CD26, DPP4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g0c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g0c RCSB], [http://www.ebi.ac.uk/pdbsum/3g0c PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g0c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g0c RCSB], [http://www.ebi.ac.uk/pdbsum/3g0c PDBsum]</span></td></tr>
-<table>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/DPP4_HUMAN DPP4_HUMAN]] Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.<ref>PMID:10951221</ref> <ref>PMID:17549790</ref> <ref>PMID:10570924</ref> <ref>PMID:10900005</ref> <ref>PMID:11772392</ref> <ref>PMID:14691230</ref> <ref>PMID:16651416</ref> <ref>PMID:17287217</ref> <ref>PMID:18708048</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 36: / Line 38: @@
 [[Category: Dipeptidyl-peptidase IV]]
 [[Category: Homo sapiens]]
-[[Category: Aertgeerts, K.]]
+[[Category: Aertgeerts, K]]
-[[Category: Feng, J.]]
+[[Category: Feng, J]]
-[[Category: Gwaltney, S L.]]
+[[Category: Gwaltney, S L]]
-[[Category: Jennings, A.]]
+[[Category: Jennings, A]]
-[[Category: Kaldor, S W.]]
+[[Category: Kaldor, S W]]
-[[Category: Kassel, D.]]
+[[Category: Kassel, D]]
-[[Category: Lee, B.]]
+[[Category: Lee, B]]
-[[Category: Shi, L.]]
+[[Category: Shi, L]]
-[[Category: Skene, R J.]]
+[[Category: Skene, R J]]
-[[Category: Stafford, J A.]]
+[[Category: Stafford, J A]]
-[[Category: Wallace, M B.]]
+[[Category: Wallace, M B]]
-[[Category: Webb, D R.]]
+[[Category: Webb, D R]]
-[[Category: Xu, R.]]
+[[Category: Xu, R]]
-[[Category: Zhang, Z.]]
+[[Category: Zhang, Z]]
 [[Category: Aminopeptidase]]
 [[Category: Cell membrane]]