3b7k: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3b7k]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3B7K FirstGlance]. <br>
<table><tr><td colspan='2'>[[3b7k]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3B7K FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene><br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ACOT12, CACH, CACH1, STARD12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ACOT12, CACH, CACH1, STARD12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetyl-CoA_hydrolase Acetyl-CoA hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.1 3.1.2.1] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetyl-CoA_hydrolase Acetyl-CoA hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.1 3.1.2.1] </span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b7k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3b7k RCSB], [http://www.ebi.ac.uk/pdbsum/3b7k PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b7k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3b7k RCSB], [http://www.ebi.ac.uk/pdbsum/3b7k PDBsum]</span></td></tr>
<table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/ACO12_HUMAN ACO12_HUMAN]] Hydrolyzes acetyl-CoA to acetate and CoA.<ref>PMID:16951743</ref> 
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Thioesterase|Thioesterase]]
*[[Thioesterase|Thioesterase]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Acetyl-CoA hydrolase]]
[[Category: Acetyl-CoA hydrolase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith, C H]]
[[Category: Berg, S Van Den.]]
[[Category: Berg, S Van Den]]
[[Category: Berglund, H.]]
[[Category: Berglund, H]]
[[Category: Busam, R D.]]
[[Category: Busam, R D]]
[[Category: Collins, R.]]
[[Category: Collins, R]]
[[Category: Dahlgren, L G.]]
[[Category: Dahlgren, L G]]
[[Category: Edwards, A M.]]
[[Category: Edwards, A M]]
[[Category: Flodin, S.]]
[[Category: Flodin, S]]
[[Category: Flores, A.]]
[[Category: Flores, A]]
[[Category: Graslund, S.]]
[[Category: Graslund, S]]
[[Category: Hallberg, B M.]]
[[Category: Hallberg, B M]]
[[Category: Hammarstrom, M.]]
[[Category: Hammarstrom, M]]
[[Category: Herman, M D.]]
[[Category: Herman, M D]]
[[Category: Johansson, A.]]
[[Category: Johansson, A]]
[[Category: Johansson, I.]]
[[Category: Johansson, I]]
[[Category: Kallas, A.]]
[[Category: Kallas, A]]
[[Category: Karlberg, T.]]
[[Category: Karlberg, T]]
[[Category: Kotenyova, T.]]
[[Category: Kotenyova, T]]
[[Category: L., Svensson.]]
[[Category: L., Svensson]]
[[Category: Lehtio, L.]]
[[Category: Lehtio, L]]
[[Category: Moche, M.]]
[[Category: Moche, M]]
[[Category: Nilsson, M E.]]
[[Category: Nilsson, M E]]
[[Category: Nordlund, P.]]
[[Category: Nordlund, P]]
[[Category: Nyman, T.]]
[[Category: Nyman, T]]
[[Category: Persson, C.]]
[[Category: Persson, C]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Structural genomic]]
[[Category: Sagemark, J.]]
[[Category: Sagemark, J]]
[[Category: Sundstrom, M.]]
[[Category: Sundstrom, M]]
[[Category: Thorsell, A G.]]
[[Category: Thorsell, A G]]
[[Category: Tresaugues, L.]]
[[Category: Tresaugues, L]]
[[Category: Weigelt, J.]]
[[Category: Weigelt, J]]
[[Category: Welin, M.]]
[[Category: Welin, M]]
[[Category: Fatty acid metabolism]]
[[Category: Fatty acid metabolism]]
[[Category: Hotdog fold]]
[[Category: Hotdog fold]]
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[[Category: Serine esterase]]
[[Category: Serine esterase]]
[[Category: Sgc]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]

Revision as of 22:46, 25 December 2014

Human Acyl-coenzyme A thioesterase 12Human Acyl-coenzyme A thioesterase 12

Structural highlights

3b7k is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:ACOT12, CACH, CACH1, STARD12 (Homo sapiens)
Activity:Acetyl-CoA hydrolase, with EC number 3.1.2.1
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[ACO12_HUMAN] Hydrolyzes acetyl-CoA to acetate and CoA.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Suematsu N, Isohashi F. Molecular cloning and functional expression of human cytosolic acetyl-CoA hydrolase. Acta Biochim Pol. 2006;53(3):553-61. Epub 2006 Sep 2. PMID:16951743

3b7k, resolution 2.70Å

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