2vc4: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2vc4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VC4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VC4 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2vc4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VC4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VC4 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1apg|1apg]], [[1br5|1br5]], [[1br6|1br6]], [[1j1m|1j1m]], [[1obs|1obs]], [[1obt|1obt]], [[1uq4|1uq4]], [[1zam|1zam]], [[1zb2|1zb2]], [[2aai|2aai]], [[1fmp|1fmp]], [[1ifs|1ifs]], [[1ift|1ift]], [[1ifu|1ifu]], [[1il3|1il3]], [[1il4|1il4]], [[1il5|1il5]], [[1il9|1il9]], [[1rtc|1rtc]], [[1uq5|1uq5]], [[1zb0|1zb0]], [[2vc3|2vc3]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1apg|1apg]], [[1br5|1br5]], [[1br6|1br6]], [[1j1m|1j1m]], [[1obs|1obs]], [[1obt|1obt]], [[1uq4|1uq4]], [[1zam|1zam]], [[1zb2|1zb2]], [[2aai|2aai]], [[1fmp|1fmp]], [[1ifs|1ifs]], [[1ift|1ift]], [[1ifu|1ifu]], [[1il3|1il3]], [[1il4|1il4]], [[1il5|1il5]], [[1il9|1il9]], [[1rtc|1rtc]], [[1uq5|1uq5]], [[1zb0|1zb0]], [[2vc3|2vc3]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vc4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vc4 RCSB], [http://www.ebi.ac.uk/pdbsum/2vc4 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vc4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vc4 RCSB], [http://www.ebi.ac.uk/pdbsum/2vc4 PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/RICI_RICCO RICI_RICCO]] Ricin is highly toxic to animal cells and to a lesser extent to plant cells. The A chain acts as a glycosidase that removes a specific adenine residue from an exposed loop of the 28S rRNA (A4324 in mammals), leading to rRNA breakage. As this loop is involved in elongation factor binding, modified ribosomes are catalytically inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, faster than the cell can make new ones. Therefore a single A chain molecule can kill an animal cell. The B chain binds to beta-D-galactopyranoside moieties on cell surface glycoproteins and glycolipids and facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (Lectin activity). | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Ricinus communis]] | [[Category: Ricinus communis]] | ||
[[Category: RRNA N-glycosylase]] | [[Category: RRNA N-glycosylase]] | ||
[[Category: Fulop, V | [[Category: Fulop, V]] | ||
[[Category: Marsden, C J | [[Category: Marsden, C J]] | ||
[[Category: Glycoprotein]] | [[Category: Glycoprotein]] | ||
[[Category: Glycosidase]] | [[Category: Glycosidase]] | ||